2017-07-16 11:46:36Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)
description
part of the [SW|condensin] complex, chromosomal origin condensation and segregation
part of the condensin complex, chromosomal origin condensation and segregation
proteinLength
251
geneLength
753
Gene
Coordinates
2,425,831 → 2,426,586
Gene
Phenotypes of a mutant
essential [Pubmed|12682299]
''[[gene|scpA]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]
essential [Pubmed|12682299]
''[[protein|scpA]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]
The protein
[SW|Localization]
nucleoid (Multiple) [Pubmed|16479537]
the [SW|condensin] ([[protein|Smc]])2-[[protein|ScpA]]-[[protein|ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [[protein|ParA]] [Pubmed|24440393,23475963]*the [SW|condensin] ([[protein|Smc]])2-[[protein|ScpA]]-[[protein|ScpB]] complex is loaded by [[protein|ParB]] to ''parS'' centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute [Pubmed|28154080,24440393,23475963]
nucleoid (Multiple) [Pubmed|16479537]
the [SW|condensin] ([[protein|Smc]])2-[[protein|ScpA]]-[[protein|ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [SW|Spo0J] [Pubmed|24440393,23475963]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-A104 (ypuG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/104 NBRP B. subtilis, Japan]
References
Original publications
ec
aminos
MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLYVHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLIEYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKVLKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFLAVLELMKNQLVLIEQEHNFSDIYITGSESIHGA
[SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|essential genes]
Gene
Coordinates on the chromosome (coding sequence)
2,425,831 -> 2,426,586
The protein
[SW|Interactions]
part of the [SW|condensin] complex [Pubmed|24440399,24440393]
present as stable monomer [Pubmed|22385855]
[[protein|ScpA]]-[[protein|Smc]] [Pubmed|23353789,22385855,12100548]
[[protein|ScpA]]-[[protein|ScpB]] [Pubmed|23353789,12100548]
Expression and Regulation
Operon
''[[protein|scpA]]-[[protein|scpB]]-[[protein|ypuI]]'' [Pubmed|7934830]
Expression and Regulation
Regulation
[[protein|RelA]] dependent downregulation (Class I) during stringent response [Pubmed|11948165]